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 Cell cycle and death control: long live Forkheads 
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Post Cell cycle and death control: long live Forkheads
The FOXO family of Forkhead transcription factors, FKHR (FOXO1), FKHR-L1 (FOXO3a) and AFX (FOXO4), are regulated by the phosphoinositide-3-kinase–protein-kinase-B (PI3K–PKB/c-Akt) pathway. Direct phosphorylation by PKB results in cytoplasmic retention and inactivation, inhibiting the expression of FOXO-regulated genes, which control the cell cycle, cell death, cell metabolism and oxidative stress. This pathway appears to be well conserved throughout evolution. In the nematode Caenorhabditis elegans, it affects lifespan and controls dauer formation. Recent discoveries about FOXO regulation by PI3K–PKB signalling suggest that the PI3K–PKB–FOXO pathway might participate in similar processes in higher eukaryotes.

did I fucking miss something here?
"Direct phosphorylation by PKB results in cytoplasmic retention"

http://www.cell.com/trends/biochemical- ... %2902113-8

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Mon Apr 22, 2013 4:04 am
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Post Re: Cell cycle and death control: long live Forkheads
It was fate.

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Mon Apr 22, 2013 8:28 pm
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Post Re: Cell cycle and death control: long live Forkheads
YES

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Wed Apr 24, 2013 2:38 am
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Post Re: Cell cycle and death control: long live Forkheads
We must find PKB and have him explain this!

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Wed Apr 24, 2013 3:33 am
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Post Re: Cell cycle and death control: long live Forkheads
Not hard to find, he's always on msn.

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Wed Apr 24, 2013 3:08 pm
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Post Re: Cell cycle and death control: long live Forkheads
He never added me. ;_;

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Wed Apr 24, 2013 4:02 pm
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Post Re: Cell cycle and death control: long live Forkheads
Because he thought you were poor

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Wed Apr 24, 2013 7:40 pm
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Post Re: Cell cycle and death control: long live Forkheads
Orange Juice Jones wrote:
Because he thought you were poor


;____;

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Post Re: Cell cycle and death control: long live Forkheads
msn is DEEEEAAAAAAD

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Wed Apr 24, 2013 11:11 pm
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Post Re: Cell cycle and death control: long live Forkheads
;_____________________________;

*runs off crying*

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Wed Apr 24, 2013 11:54 pm
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Post Re: Cell cycle and death control: long live Forkheads
overkill exp bonus: 3000

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Post Re: Cell cycle and death control: long live Forkheads
Level up! Level: 3
Exp to next level: 6000
Skill points: 2
Stat points: 7

Strength: 16
Constitution: 11
Dexterity: 9
Intelligence: 22
Wisdom: 13
Luck: 12

Skills:

Rest (Active, Level: 1, Max: 1)
Description: Stay immobile to gain increased HP and MP regeneration.

Lightning (Active, Level: 1, Max: 20)
Description: Short range AoE. Max enemies: 5

Fireball (Active, Level: 0, Max: 20)
Description: Single-target medium damage spell.

Curse (Active, Level: 0, Max: 10)
Description: Debuff that causes target to be under the "Blind" affect while doing small amounts of poison damage.

Shield (Toggle, Level: 1, Max: 10)
Description: Activate to cause your MP to take a percentage of any damage applied.

Warp (Active, Level: 1, Max: 2)
Description: Self-targeting spell. Warp to any town you have previously visited. Long cooldown.

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Thu Apr 25, 2013 8:16 am
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